Summary: Methylphenidate may boost norepinephrine levels in the prefrontal cortex, which in turn regulates dopaminergic neurons firing in the striatum, when a reward is delivered. Attention-deficit hyperactivity disorder (ADHD) is a neurobiological disorder characterized by symptoms of hyperactivity, inattention and impulsivity. […] Previous research suggests that people with ADHD have different brain responses when anticipating and receiving rewards, compared to individuals without ADHD. Scientists at OIST have proposed that in those with ADHD, neurons in the brain release less dopamine – a ‘feel-good’ neurotransmitter involved in reward-motivated behavior – when a reward is expected, with dopamine neurons firing more when a reward is given.

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