Researchers have identified a set of drug-like compounds, including a common ingredient in throat lozenges, that can help protect mitochondria from the stresses associated with neurodegenerative diseases.

A sophisticated new screening platform developed by scientists at Scripps Research has enabled them to discover a set of drug-like compounds, including an ingredient found in sore throat lozenges, that may powerfully protect brain cells from dangerous stresses found in Alzheimer’s and other neurodegenerative diseases.

The screening platform, described in a paper in Science Advances, allows researchers for the first time to rapidly test “libraries” of thousands of molecules to find those that provide broad protection to mitochondria in neurons.



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